Abstract: Na/Mg/F three elements co-doping hydroxyapatite ( HA) powders were prepared by chemical precipitation method in simulated body fluids environment. The phase, structure, micromorphology, chemical composition and thermal stability of the obtained powders were analyzed and characterized by XRD, FT-IR, SEM and EDS. The results show that Na/Mg/F co-doping cause the lattice distortions of HA and the doping amount of F element has some influences on the morphology of HA. With the increase of the doping amount of F element, spherical HA particles gradually transformed into the rod-like structure. When the ratio of F/P was 0. 25, HA particles with small and uniform can be obtained. The bacteriostatic ring test indicated that the Na/Mg/F co-doping HA had an inhibitory effect on growth of Staphylococcus aureus. While the ratio of F/P was 0. 25, HA powders possessed the best antibacterial activity. The phase of HA calcined at 1000 ℃ did not change showed its good thermal stability.

Key words: chemical precipitation method;simulated body fluid;ions co-doping;antibacterial activity