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硅酸盐通报 ›› 2021, Vol. 40 ›› Issue (8): 2777-2783.

• 新型功能材料 • 上一篇    下一篇

改性黄腐酸/凹凸棒石复合材料的制备及其抑菌性能

杨芳芳1,2, 张倩3, 宋亚萌1, 惠爱平1,2, 康玉茹1,2, 王爱勤1,2   

  1. 1.中国科学院兰州化学物理研究所,甘肃省黏土矿物应用研究重点实验室,兰州 730000;
    2.中国科学院兰州化学物理研究所盱眙凹土应用技术研发中心,淮安 211700;
    3.兰州大学第二医院检验医学中心,兰州 730000
  • 收稿日期:2021-02-21 修回日期:2021-04-02 出版日期:2021-08-15 发布日期:2021-09-02
  • 通讯作者: 王爱勤,博士,研究员。E-mail:aqwang@licp.cas.cn
  • 作者简介:杨芳芳(1986—),女,博士,助理研究员。主要从事抗菌材料的研究。E-mail:yangff@licp.cas.cn
  • 基金资助:
    江苏省科技厅重点研发计划(BE2019071);中国科学院STS区域重点项目(KFJ-STS-QYZX-086);兰州化学物理研究所青年合作基金(552020000093)

Prepration of Modified Fulvic Acid/Attapulgite Composites and Their Antimicrobial Properties

YANG Fangfang1,2, ZHANG Qian3, SONG Yameng1, HUI Aiping1,2, KANG Yuru1,2, WANG Aiqin1,2   

  1. 1. Key Laboratory of Clay Mineral Applied Research of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
    2. R&D Center of Xuyi Palygorskite Applied Technology, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Huai'an 211700, China;
    3. Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou 730000, China
  • Received:2021-02-21 Revised:2021-04-02 Online:2021-08-15 Published:2021-09-02

摘要: 黄腐酸(FA)具有抑菌消炎和促进动物生长的功效。为了进一步提升FA的广谱抑菌性,以凹凸棒石(APT)为载体,通过吸附法将FA负载于APT,同时进行十六烷基三甲基溴化铵(CTAB)改性。结果表明,FA和APT主要以静电吸附形式结合,CTAB的引入实现了FA/APT复合材料的电荷调控。复合材料对大肠杆菌和金黄色葡萄球菌的最小抑菌浓度(MIC)随着CTAB添加量的增加而减小;当CTAB添加量为15%(质量分数)时,其对大肠杆菌的MIC为1 mg/mL,对金黄色葡萄球菌的MIC为0.05 mg/mL。

关键词: 黄腐酸, 凹凸棒石, 十六烷基三甲基溴化铵, 复合材料, 广谱抑菌性

Abstract: Fulvic acid (FA) has the effect of inhibiting bacteria, anti-inflammation, and promoting animal growth. In order to further improve the broad-spectrum antimicrobial properties of FA, a composite was prepared by loading FA into attapulgite (APT) through the adsorption method, meanwhile cetyltrimethylammonium bromide (CTAB) was used to modify the composite. The results show that FA and APT are mainly combined by electrostatic adsorption, and the introduction of CTAB regulates the charge of FA/APT composites. The minimum inhibitory concentration (MIC) of the composites against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) decreases with the increase of CTAB amount. When the amount of CTAB is 15% (mass fraction), the MIC is 1 mg/mL for E. coli and the MIC is 0.05 mg/mL for S. aureus.

Key words: fulvic acid, attapulgite, cetyl trimethyl ammonium bromide, composite material, broad-spectrum antimicrobial property

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