氧化石墨烯辅助仿生矿化原位合成羟基磷灰石

硅酸盐通报 ›› 2024, Vol. 43 ›› Issue (1): 363-369.

氧化石墨烯辅助仿生矿化原位合成羟基磷灰石

张彪^{1, 2, 3}, 石淇铭^{1, 2}, 白梓恒^{1, 2}, 刘泓宇^{1, 2}, 马涛^{1, 2, 3}, 王芬^{1, 2, 3}, 朱建锋^{1, 2, 3}, 施佩^{1, 2, 3}

1.陕西科技大学材料科学与工程学院,西安 710021;
2.陕西科技大学文物保护科学与技术学院,西安 710021;
3.陕西省无机材料绿色制备与功能化重点实验室,西安 710021

收稿日期:2023-08-01 修订日期:2023-09-20 出版日期:2024-01-15 发布日期:2024-01-16
作者简介:张彪(1990—),男,博士,讲师。主要从事无机非金属材料方面的研究。E-mail:zhangbiao@sust.edu.cn
基金资助:
国家自然科学基金(52102108,52102026,52272020);中国博士后科学基金面上资助(2021M691997);陕西省教育厅重点科研计划(22JY009,22JY010)

In-Situ Synthesis of Hydroxyapatite by Biomimetic Mineralization Assisted by Graphene Oxide

ZHANG Biao^1,2,3, SHI Qiming^1,2, BAI Ziheng^1,2, LIU Hongyu^1,2, MA Tao^1,2,3, WANG Fen^1,2,3, ZHU Jianfeng^1,2,3, SHI Pei^1,2,3

1. School of Material Science & Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China;
2. School of Antiquities Preservation Science & Technology, Shaanxi University of Science & Technology, Xi’an 710021, China;
3. Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Xi’an 710021, China

Received:2023-08-01 Revised:2023-09-20 Online:2024-01-15 Published:2024-01-16

摘要/Abstract

摘要： 羟基磷灰石(HAp)是一种与人体骨骼成分类似的无机材料,具有良好的生物相容性。本文以氧化石墨烯(GO)为模板,通过模拟体液(SBF)仿生矿化原位合成了HAp纳米粒子。通过SEM、XRD、EDS和拉曼光谱等测试分析研究了矿化时间、SBF/GO体积比对矿化产物物相组成、形貌和结构的影响。结果表明,矿化处理后的GO表面形成了大量均匀分布的类骨HAp。随着矿化时间延长和SBF体积占比增大,矿化产物的尺寸及数量增大,GO层间距逐渐扩大。本研究验证了GO辅助合成HAp的可行性,拓展了仿生矿化法的应用领域。

关键词: 仿生矿化, 氧化石墨烯, 羟基磷灰石, 模拟体液, 原位合成, 粒径变化

Abstract: Hydroxyapatite (HAp) is an inorganic material similar to human bone, with good biocompatibility. In this paper, HAp nanoparticles were in-situ synthesized using simulated body fluid (SBF) biomimetic mineralization method with graphene oxide (GO) as a template. The effects of mineralization time and volume ratio of SBF to GO on the phase composition, morphology, and structure of mineralization products were studied through testing and analysis of SEM, XRD, EDS and Raman spectroscopy. The results show that a large amount of uniformly distributed bone-like HAp is formed on the surface of GO after mineralization treatment. With the extension of mineralization time and the increase of volume proportion of SBF, the size and quantity of mineralization products increase, and the interlayer spacing of GO gradually expands. This study verifies the feasibility of synthesis of HAp nanoparticles assisted by graphene oxide, and expands the application field of biomimetic mineralization method.

Key words: biomimetic mineralization, graphene oxide, hydroxyapatite, simulated body fluid, in-situ synthesis, particle size change

中图分类号:

TB321

张彪, 石淇铭, 白梓恒, 刘泓宇, 马涛, 王芬, 朱建锋, 施佩. 氧化石墨烯辅助仿生矿化原位合成羟基磷灰石[J]. 硅酸盐通报, 2024, 43(1): 363-369.

ZHANG Biao, SHI Qiming, BAI Ziheng, LIU Hongyu, MA Tao, WANG Fen, ZHU Jianfeng, SHI Pei. In-Situ Synthesis of Hydroxyapatite by Biomimetic Mineralization Assisted by Graphene Oxide[J]. BULLETIN OF THE CHINESE CERAMIC SOCIETY, 2024, 43(1): 363-369.

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