Abstract: Quaternized KGM (CMKGM) was used to modify montmorillonite (MMT) to prepare organic montmorillonite (CMKGM-MMT).The structure of modified montmorillonite was characterized by infrared spectroscopy (FT-IR) and X-ray diffraction (XRD).The results show that quaternized KGM indeed intercalate into the layers of montmorillonite and form intercalated organic montmorillonite with the highest organic modification when the amount of CMKGM is equivalent to 1.0 CEC of MMT(the mass ratio between CMKGM and MMT is 0.9) under the condition of 60 ℃ at pH=4.6.Then the in vitro cytotoxicity and the drug loading property of the complexes were investigated.

Key words: montmorillonite;konjac glucomannan;intercalation;organic modification