Abstract: The particle size of silica microspheres synthesized by sol-gel method was optimized by response surface method.The effect of single factor on particle size was studied and discussed.Based on the experimental conditions selected by the single factor experiment, the experiment was designed according to the response surface method.The data were analyzed by quadratic regression and variance analysis and the insignificant terms are deleted and refitted to make the model reflect the actual situation better.Based on the fitted model, the influence of the interaction was analyzed.The suitable range of sol-gel method and the synthesis conditions of specific particle size were predicted.It is found that the error value is within 100 nm, which can provide a good reference for the later researchers.

Key words: response surface methodology;sol gel;silica microsphere;particle size