IP6-HA改性磷酸镁基复合骨水泥的制备与性能研究

摘要/Abstract

摘要： 本文以氧化镁(MgO)和磷酸二氢钾(KH₂PO₄)作为磷酸镁骨水泥的固相成分,并引入不同含量的植酸改性羟基磷灰石(IP6-HA)粉末,制备多种不同镁磷比的磷酸镁基复合骨水泥。通过调整磷酸镁粉末中MgO和KH₂PO₄的比例和IP6-HA含量,改善了骨水泥的力学性能和固化时间,并研究了骨水泥的固化机理。结果表明,当镁磷比为4且固相中的IP6-HA含量为5%(质量分数)时,鸟粪石晶体(MgKPO₄·6H₂O)的生长效果最好,固化时间为7.5 min,抗压强度可达49 MPa,固化四周后强度可达69.3 MPa。试验所得的IP6-HA改性磷酸镁基复合骨水泥力学性能较好且固化时间适宜,具有潜在的生物医学应用前景。

关键词: 骨水泥, 磷酸盐, 氧化镁, 羟基磷灰石, 固化时间, 力学性能

Abstract: In this paper, magnesium oxide (MgO) and potassium dihydrogen phosphate (KH₂PO₄) were used as the solid phase components of magnesium phosphate bone cement, and different content of phytic acid modified hydroxyapatite (IP6-HA) powder was introduced to prepare various magnesium phosphate composite bone cement with different magnesium and phosphorus ratio (M∶P). By adjusting the ratio of MgO and KH₂PO₄ in magnesium phosphate powder and the content of IP6-HA, the mechanical properties and curing time of bone cement were improved, and the curing mechanism of bone cement was studied. The results show that when the ratio of magnesium to phosphorus is 4 and the content of IP6-HA in the solid phase is 5% (mass fraction), the growth effect of struvite crystals (MgKPO₄·6H₂O) is the best, the curing time is 7.5 min, the compressive strength can reach 49 MPa, and the strength can reach 69.3 MPa after curing for four weeks. The IP6-HA modified magnesium phosphate composite bone cement obtained from the experiment has good mechanical properties and suitable curing time, which has potential biomedical application prospects.

Key words: bone cement, phosphate, magnesium oxide, hydroxyapatite, curing time, mechanical property

中图分类号:

TB321

王嘉毅, 汪涛, 聂云鹏, 王琪. IP6-HA改性磷酸镁基复合骨水泥的制备与性能研究[J]. 硅酸盐通报, 2023, 42(8): 2888-2894.

WANG Jiayi, WANG Tao, NIE Yunpeng, WANG Qi. Preparation and Properties of IP6-HA Modified Magnesiu Phosphate Based Composite Bone Cement[J]. BULLETIN OF THE CHINESE CERAMIC SOCIETY, 2023, 42(8): 2888-2894.

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