磁性羟基磷灰石制备的研究进展

摘要/Abstract

摘要： 羟基磷灰石(HAP)是一种典型的生物活性材料,已在骨外科、牙科临床等方面得到了广泛的应用。由于HAP比表面积大,吸附能力强,HAP在药物递送、污水处理等领域也得到了广泛应用。磁性纳米颗粒具有良好的电磁性能、可回收性和电磁制热性能,已受到越来越多的关注。近年来,为了结合以上两种材料的优点,将磁性材料与羟基磷灰石相结合是上述领域研究应用的重点方向。此前,有综述报道过关于磁性羟基磷灰石复合材料的制备研究,但重点关注于与其他材料的复合,缺乏针对磁性羟基磷灰石制备方法的系统总结。本文以掺杂和包覆两种将磁性引入羟基磷灰石的方式为出发点,系统总结了磁性羟基磷灰石的经典制备方法及其优缺点,并讨论了其相关应用,特别是论述了进一步研究拓展的关键问题以及今后的研究趋势,以期为磁性羟基磷灰石的深入拓展提供参考。

关键词: 生物材料, 羟基磷灰石, 磁性, 掺杂, 包覆, 原位复合, 机械混合

Abstract: Hydroxyapatite (HAP) is a typical biomaterial, and has been widely used in the bone surgery and dental restoration. Owing to its large specific surface area and high absorbability, HAP has also been used in drug delivery and wastewater treatment. Due to its good electromagnetic property, easy recyclability, and distinct magneto thermoelectric effect, magnetic nanoparticles also gain more attention. To take both advantages, the combination of magnetic materials and HAP has become an important research direction in recent years. Although the preparation of hydroxyapatite composite materials in the past was reported, most of them only focused on the compositing materials and lacked the systematic summary on the synthesis methods. Based on the two ways of introducing magnetism into hydroxyapatite, doping and coating, the classical preparation methods, advantages and disadvantages of magnetic hydroxyapatite as well as the related applications were reviewed. The key problems of further research and future trends were discussed, in order to provide reference for the in-depth research and development of magnetic hydroxyapatite.

Key words: biomaterial, hydroxyapatite, magnetism, doping, coating, in situ composition, mechanical mixing

中图分类号:

TB332

李静, 刘金坤, 颜廷亭, 冷崇燕, 陈希亮, 陈庆华. 磁性羟基磷灰石制备的研究进展[J]. 硅酸盐通报, 2022, 41(1): 302-311.

LI Jing, LIU Jinkun, YAN Tingting, LENG Chongyan, CHEN Xiliang, CHEN Qinghua. Research Progress on Preparation of Magnetic Hydroxyapatite[J]. BULLETIN OF THE CHINESE CERAMIC SOCIETY, 2022, 41(1): 302-311.

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